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KMID : 0616120080390020127
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Korean Journal of Pharmacognosy
2008 Volume.39 No. 2 p.127 ~ p.134
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Isolation and Oxidation Characteristics of Alkaloids of Aconitum volubile
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Heo Kyong-Hee
Lee Chung-Kyu
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Abstract
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From the under ground part of Aconitum volubile Pall. (Ranunculaceae), seven nor- or di-terpenoid alkaloids were isolated and identified by NMR spectra and mass spectrum. The alkaloids were three C19-norditerpenoid alkaloids such as isotalatizidine, altaconitine and vilmorrianine A, and four C20-diterpenoid alkaloids such as 12-epidehydronapelline, 12-epinapelline, songoramine and songorine. Some of the isolated diterpenoid alkaloids were subjected to oxidation reaction with active MnO2 and oxoammonium salt. The results were C-12 oxidation(ketone formation) and N-dealkylation in veatchin-type and decomposition to non-alkaloidal compounds in atisine-type ajaconine.
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KEYWORD
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norditerpenoid alkaloid, diterpenoid alkaloid, isotalatizidine, altaconitine, vilmorrianine A, 12-epidehydronapelline, 12-epinapelline, songoramine, songorine, oxidation, active MnO2, oxoammonium salt
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